Comment on

• Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.

  Adrain C, Zettl M, Christova Y, Taylor N, Freeman M. Adrain C, et al. Science. 2012 Jan 13;335(6065):225-8. doi: 10.1126/science.1214400. Science. 2012. PMID: 22246777 Free PMC article.
• iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

  McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. McIlwain DR, et al. Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448. Science. 2012. PMID: 22246778 Free PMC article.