Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;50(1):35-9.
doi: 10.3164/jcbn.11-115SR. Epub 2011 Dec 9.

Roles of oxidative stress in stomach disorders

Hidekazu Suzuki  1 , Toshihiro Nishizawa, Hitoshi Tsugawa, Sachiko Mogami, Toshifumi Hibi
Affiliations

Roles of oxidative stress in stomach disorders

Hidekazu Suzuki et al. J Clin Biochem Nutr. 2012 Jan.

Abstract

The stomach is a sensitive digestive organ that is susceptible and exposed to exogenous pathogens from the diet. In response to such pathogens, the stomach induces oxidative stress, which might be related to the development of gastric organic disorders such as gastritis, gastric ulcers, and gastric cancer, as well as functional disorders such as functional dyspepsia. In particular, the bacterium Helicobacter pylori plays a major role in eliciting and confronting oxidative stress in the stomach. The present paper summarizes the pathogenesis of oxidative stress in the stomach during the development of various stomach diseases.

Keywords: Helicobacter pylori; gastric mucosa; oxidative stress.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Homology modeling of Helicobacter pylori SodB. Four amino acids (His 26, His 73, His 160, and Asp 156) of SodB are ferrous ion (Fe2+)-coordinating residues (i.e., an iron-binding domain).
See this image and copyright information in PMC

References

    1. Suzuki H, Iwasaki E, Hibi T. Helicobacter pylori and gastric cancer. Gastric Cancer. 2009;12:79–87. - PubMed
    1. Suzuki H, Matsuzaki J, Hibi T. Ghrelin and oxidative stress in gastrointestinal tract. J Clin Biochem Nutr. 2011;48:122–125. - PMC - PubMed
    1. Pan JS, He SZ, Xu HZ, et al. Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury. World J Gastroenterol. 2008;14:5857–5867. - PMC - PubMed
    1. Kinjo N, Kawanaka H, Akahoshi T, et al. Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1016–G1024. - PubMed
    1. Suzuki M, Miura S, Mori M, et al. Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. Gut. 1994;35:1375–1378. - PMC - PubMed