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. 2010 Jul;1(3):326-9.
doi: 10.4103/0110-5558.72427.

Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method

S C Arora  1 , P K Sharma, Raghuveer Irchhaiya, Anurag Khatkar, Neeraj Singh, Jagbir Gagoria
Affiliations

Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method

S C Arora et al. J Adv Pharm Technol Res. 2010 Jul.

Abstract

Cefuroxime Axetil (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. Therefore, the main purpose of this investigation was to increase the solubility and dissolution rate of Cefuroxime Axetil by the preparation of its solid dispersion with urea, using the solvent evaporation method. Physical mixtures and solid dispersions of Cefuroxime Axetil were prepared by using urea as a water-soluble carrier in various proportions (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, and 1:7 by weight), by employing the solvent evaporation method. The drug release profile was studied and it was found that the dissolution rate and the dissolution parameters of the drug from the physical mixture as well as solid dispersion were higher than those of the intact drug. The Fourier Transform Infrared (FTIR) spectra revealed no chemical incompatibility between the drug and urea. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC) and Powder X-Ray Diffraction (PXRD).

Keywords: Cefuroxime Axetil; solid dispersion; solvent evaporation method; urea.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Chemical structure of Cefuroxime Axetil
Figure 2
Figure 2
Differential scanning calorimetry of Cefuroxime Axetil
Figure 3
Figure 3
Comparative in vitro release profiles of Cefuroxime Axetil from solid dispersions and physical mixture containing urea
See this image and copyright information in PMC

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