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Review
. 2012 Apr;14(2):158-65.
doi: 10.1007/s11912-012-0216-1.

Functional outcomes after chemoradiotherapy of laryngeal and pharyngeal cancers

Katherine A Hutcheson  1 , Jan S Lewin
Affiliations
Review

Functional outcomes after chemoradiotherapy of laryngeal and pharyngeal cancers

Katherine A Hutcheson et al. Curr Oncol Rep. 2012 Apr.

Abstract

Organ preservation regimens that combine chemotherapy and radiotherapy (chemoradiotherapy) are increasingly used as the primary treatment of laryngeal and pharyngeal cancers. Meta-analytic data show a survival benefit with combined modality therapy, but the functional sequelae can be significant. Dysphagia is recognized as a common and often devastating late effect of chemoradiotherapy. This review examines functional outcomes after chemoradiotherapy for laryngeal and pharyngeal cancers, with a particular emphasis on dysphagia. Topics examined include the burden of dysphagia after chemoradiation, pathophysiology of dysphagia, baseline functioning, recommendations to improve long-term function, and voice outcomes.

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