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Case Reports
. 2012 Dec;31(4):338-40.
doi: 10.3109/15569527.2011.647180. Epub 2012 Jan 18.

Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis

Katherine Gordon  1 , Maria Miteva, Daniele Torchia, Paolo Romanelli
Affiliations
Case Reports

Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis

Katherine Gordon et al. Cutan Ocul Toxicol. 2012 Dec.

Abstract

We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is known to rarely cause granulomatous reactions, but this appears to be the first case of palisading neutrophilic granulomatous dermatitis induction. Possible mechanisms include immune complex deposition, an immune response directed against the metabolites of allopurinol, or allopurinol hypersensitivity exclusively localized to the skin.

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