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Review
. 2012 Jan 18;13(2):67-73.
doi: 10.1038/nrm3267.

Illuminating the functional and structural repertoire of human TBC/RABGAPs

Marieke A M Frasa  1 , Katja T Koessmeier, M Reza Ahmadian, Vania M M Braga
Affiliations
Review

Illuminating the functional and structural repertoire of human TBC/RABGAPs

Marieke A M Frasa et al. Nat Rev Mol Cell Biol. .

Erratum in

  • Nat Rev Mol Cell Biol. 2012 Jul;13(7):476

Abstract

The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.

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