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. 2012 Mar;27(3):637-40.
doi: 10.1093/humrep/der464. Epub 2012 Jan 16.

Should androgen supplementation be used for poor ovarian response in IVF?

Sesh Kamal Sunkara  1 , Arri Coomarasamy, Wiebke Arlt, Siladitya Bhattacharya
Affiliations

Should androgen supplementation be used for poor ovarian response in IVF?

Sesh Kamal Sunkara et al. Hum Reprod. 2012 Mar.

Abstract

Poor ovarian response is reported in 9-24% of IVF cycles. Several interventions have been proposed to improve the outcome, although evidence to support these has been scant. There has been interest in the use of adjuvant androgens in this context and a recent worldwide survey showed that nearly a quarter of IVF clinicians used dehydroepiandrosterone (DHEA) in poor responders. We examine the rationale for the use of adjuvant androgens and suggest that the current clinical uncertainty should be addressed by a randomized controlled trial of DHEA in poor responders.

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