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. 2012 Apr;56(4):2146-9.
doi: 10.1128/AAC.05566-11. Epub 2012 Jan 17.

Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age

Inoni Betuela  1 , Quique Bassat, Benson Kiniboro, Leanne J Robinson, Anna Rosanas-Urgell, Danielle Stanisic, Peter M Siba, Pedro L Alonso, Ivo Mueller
Affiliations

Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age

Inoni Betuela et al. Antimicrob Agents Chemother. 2012 Apr.

Abstract

Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.

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Figures

Fig 1
Fig 1
Trial design and drugs administered in the two different study cohorts. (Upper panel) Albinama cohort (5 to 10 years of age). (Lower panel) Ilaita cohort (1 to 5 years of age).
See this image and copyright information in PMC

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