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Comparative Study
. 2012 Apr;56(4):2150-2.
doi: 10.1128/AAC.05918-11. Epub 2012 Jan 17.

Case-control study comparing de novo and daptomycin-exposed daptomycin-nonsusceptible Enterococcus infections

Theodoros Kelesidis  1 , Angela L P Chow, Romney Humphries, Daniel Z Uslan, David Pegues
Affiliations
Comparative Study

Case-control study comparing de novo and daptomycin-exposed daptomycin-nonsusceptible Enterococcus infections

Theodoros Kelesidis et al. Antimicrob Agents Chemother. 2012 Apr.

Abstract

Understanding factors associated with de novo daptomycin-nonsusceptible Enterococcus (DNSE) infections will aid in better understanding the mechanisms of daptomycin nonsusceptibility. We conducted a case-control study to compare patients with DNSE infections who were daptomycin treatment naïve (n = 9) and those with DNSE infections who had exposure to daptomycin (n = 13). Less frequent exposure to antimicrobials, increased susceptibility to nitrofurantoin and gentamicin, and shorter duration of hospitalization were associated with de novo DNSE infection, suggesting a potential community reservoir.

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