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. 2012 Apr 1;302(7):E800-6.
doi: 10.1152/ajpendo.00598.2011. Epub 2012 Jan 17.

Higher ghrelin and lower leptin secretion are associated with lower LH secretion in young amenorrheic athletes compared with eumenorrheic athletes and controls

Kathryn E Ackerman  1 , Katherine Slusarz, Gabriela Guereca, Lisa Pierce, Meghan Slattery, Nara Mendes, David B Herzog, Madhusmita Misra
Affiliations

Higher ghrelin and lower leptin secretion are associated with lower LH secretion in young amenorrheic athletes compared with eumenorrheic athletes and controls

Kathryn E Ackerman et al. Am J Physiol Endocrinol Metab. .

Abstract

Amenorrhea is common in young athletes and is associated with low fat mass. However, hormonal factors that link decreased fat mass with altered gonadotropin pulsatility and amenorrhea are unclear. Low levels of leptin (an adipokine) and increased ghrelin (an orexigenic hormone that increases as fat mass decreases) impact gonadotropin pulsatility. Studies have not examined luteinizing hormone (LH) secretory dynamics in relation to leptin or ghrelin secretory dynamics in adolescent and young adult athletes. We hypothesized that 1) young amenorrheic athletes (AA) would have lower LH and leptin and higher ghrelin secretion than eumenorrheic athletes (EA) and nonathletes and 2) higher ghrelin and lower leptin would be associated with lower LH secretion. This was a cross-sectional study. We examined ghrelin and leptin secretory patterns (over 8 h, from 11 PM to 7 AM) in relation to LH secretory patterns in AA, EA, and nonathletes aged 14-21 yr. Ghrelin and leptin were assessed every 20 min and LH every 10 min. Groups did not differ for age, bone age, or BMI. However, fat mass was lower in AA than in EA and nonathletes. AA had lower LH and higher ghrelin pulsatile secretion and AUC than nonathletes and lower leptin pulsatile secretion and AUC than EA and nonathletes. Percent body fat was associated positively with LH and leptin secretion and inversely with ghrelin. In a regression model, ghrelin and leptin secretory parameters were associated independently with LH secretory parameters. We conclude that higher ghrelin and lower leptin secretion in AA related to lower fat mass may contribute to altered LH pulsatility and amenorrhea.

Trial registration: ClinicalTrials.gov NCT00946192.

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Figures

Fig. 1.
Fig. 1.
LH, ghrelin, and leptin concentrations over the sampling period in an amenorrheic athlete, an eumenorrheic athlete, and a nonathlete.
Fig. 2.
Fig. 2.
Associations between ghrelin and leptin pulse mass with LH pulse mass for the group as a whole and within amenorrheic athletes. Top: inverse association of ghrelin pulse mass with LH pulse mass for all subjects (left) and amenorrheic athletes (right). Bottom: positive associations of leptin pulse mass with LH pulse mass for all subjects (left) and amenorrheic athletes (right). Correlation coefficients and P values are indicated in the figure.
See this image and copyright information in PMC

References

    1. Ackerman KE, Nazem T, Chapko D, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls. J Clin Endocrinol Metab 96: 3123–3133, 2011 - PMC - PubMed
    1. Apter D, Butzow TL, Laughlin GA, Yen SS. Gonadotropin-releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins. J Clin Endocrinol Metab 76: 940–949, 1993 - PubMed
    1. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91: 456–488, 2009 - PubMed
    1. Barkan D, Hurgin V, Dekel N, Amsterdam A, Rubinstein M. Leptin induces ovulation in GnRH-deficient mice. FASEB J 19: 133–135, 2005 - PubMed
    1. Buggs C, Rosenfield RL. Polycystic ovary syndrome in adolescence. Endocrinol Metab Clin North Am 34: 677–705, x, 2005 - PMC - PubMed

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