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Case Reports
. 2011 Dec;48(12):969-71.
doi: 10.1007/s13312-011-0144-4.

Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis

Mi Jin Kim  1 , Kee Taek Jang, Yon Ho Choe
Affiliations
Case Reports

Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis

Mi Jin Kim et al. Indian Pediatr. 2011 Dec.

Erratum in

  • Indian Pediatr. 2012 Jan;49(1):16

Abstract

Sweet syndrome is a cutaneous lesion characterized by tender, red inflammatory nodules or papules. We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine. As azathioprine is widely used in children with inflammatory bowel disease, clinicians should be aware of this unusual adverse reaction.

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References

    1. Garey K.W., Streetman D.S., Rainish M.C. Azathioprine hypersensitivity reaction in a patient with ulcerative colitis. Ann Pharmacother. 1998;32:425–428. doi: 10.1345/aph.17395. - DOI - PubMed
    1. Paoluzi O.A., Crispino P., Amantea A., Pica R., Iacopini F., Consolazio A., et al. Diffuse febrile dermatosis in a patient with active ulcerative colitis under treatment with steroids and azathioprine: a case of Sweet’s syndrome. Case report and review of literature. Dig Liver Dis. 2004;36:361–366. doi: 10.1016/j.dld.2003.10.020. - DOI - PubMed
    1. El-Azhary R.A., Brunner K.L., Gibson L.E. Sweet syndrome as a manifestation of azathioprine hypersensitivity. Mayo Clin Proc. 2008;83:1026–1030. doi: 10.4065/83.9.1026. - DOI - PubMed
    1. Yiasemides E., Thom G. Azathioprine hypersensitivity presenting as a neutrophilic dermatosis in a man with ulcerative colitis. Australas J Dermatol. 2009;50:48–51. doi: 10.1111/j.1440-0960.2008.00503.x. - DOI - PubMed
    1. Su W.P., Liu H.N. Diagnostic criteria for Sweet’s syndrome. Cutis. 1986;37:167–174. - PubMed
References
    1. Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic. Influenza, Bautista E., Chotpitayasunondh T., Gao Z., Harper S.A., Shaw M., et al. Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection. N Engl J Med. 2010;362:1708–1719. doi: 10.1056/NEJMra1000449. - DOI - PubMed
    1. Press Release from Press Information Bureau, Press Release. Government of India, May 26,2010, http://pib.nic.in/h1n1/h1n1.asp.
    1. Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) — United States, May–August 2009. MMWR Morb Mortal Wkly Rep. 2009;58:1071–1074. - PubMed
    1. Seiter K., Nadelman R.B., Liu D., Ahmad T., Montecalvo M.A. Novel influenza A (H1N1) in patients with hematologic malignancies. J Clin Oncol. 2010;28:e27–e29. doi: 10.1200/JCO.2009.25.8889. - DOI - PubMed
    1. Saurez J.G., Martin Y., Callejas M., Rodriguez-Dominguez M., Galán J.C., Burgaleta C., et al. Favourable outcome of pneumonia due to novel influenza A/H1N1 2009 virus in a splenectomised adult patient undergoing therapy for non Hodgkin lymphoma. Br J Haematol. 2010;148:805–814. doi: 10.1111/j.1365-2141.2009.07989.x. - DOI - PubMed
References
    1. Ditullio M.V. Intramedullary spinal cord abscess: case report with review of 53 previously described cases. Surg Neurol. 1997;7:351–354. - PubMed
    1. Menezes A.H., Graf C.J., Perret G.E. Spinal cord abscess: review. Surgical Neurology. 1977;8:461–467. - PubMed
    1. Benzyl D., Epstein M.H., Knuckey N.W. Intramedullary epidermoid associated with an intramedullary spinal abscess secondary to a dermal sinus. Neurosurgery. 1992;30:118–121. doi: 10.1227/00006123-199201000-00022. - DOI - PubMed
    1. Murphy K.J., Brunberg J.A., Quit D.J., Kazanjian P.H. Spinal cord infection: myelitis and abscess formation. AJNR AM J Neuroradiol. 1998;19:341–348. - PMC - PubMed
    1. Hoda M.F., Prasad R., Singh V.P., Maurya P., Singh K., Sharma V. Spinal intramedullary tubercular abscess: a case report. Indian J Tuberc. 2005;52:211–214.
References
    1. Kliegman M.R., Behrman R.E., Jenson H.B., Stanton B.F., editors. Strongyloidiasis (Strongyloides Stercoralis). Nelson Textbook of Pediatrics. 18th Ed. Philadelphia (Pennsylvania): Saunders; 2008. pp. 1501–1502.
    1. Daubenton J.D., Buys H.A., Hartley P.S. Disseminated strongyloidiasis in a child with lymphoblastic lymphoma. J Pediatr Hematol Oncol. 1998;20:260–263. doi: 10.1097/00043426-199805000-00014. - DOI - PubMed
    1. Sarubbi F.A. Hyperinfection with strongyloides during treatment of pemphigus vulgaris. Arch Dermatol. 1987;123:864–865. doi: 10.1001/archderm.1987.01660310028005. - DOI - PubMed
    1. Reddy I.S., Swarnalata G. Fatal disseminated Strongyloidiasis in patients on immunosuppressive therapy: Report of two cases. Indian J Dermato Venerol Leprol. 2005;71:38–40. doi: 10.4103/0378-6323.13785. - DOI - PubMed
    1. Marcos L.A., Terashima A., Dupont H.L., Gotuzzo E. Strongyloides hyperinfection syndrome: an emerging global infectious disease. Trans R Soc Trop Med Hyg. 2008;102:314–318. doi: 10.1016/j.trstmh.2008.01.020. - DOI - PubMed
References
    1. Chalumeau M., Clainche Le L., Sayeg N., Sannier N., Michel L.J., Marianowski R., et al. Spontaneous pneumomediastinum in children. Pediatr Pulmnol. 2001;31:67–75. doi: 10.1002/1099-0496(200101)31:1<67::AID-PPUL1009>3.0.CO;2-J. - DOI - PubMed
    1. Hasegawa M., Hashimoto K., Moruzumi M., Ubukata K., Takahashi T., Inamo Y. Spontaneous pneumomediastinum complicating pneumonia in children infected with 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect. 2010;16:195–199. doi: 10.1111/j.1469-0691.2009.03086.x. - DOI - PubMed
    1. Patric LC. Pneumomediastinum: treatment and medication. Available from http://emedicine medscape.com/article//1003409-treatment. Accessed on March 30, 2010.
    1. Tonelli R.A., Ruiz-Rodriguezs O., Jeminez J.E. Successful use of high-frequency oscillator ventilation for acute respiratory distress syndrome with pneumomediastinum. Respiratory Medicine CME. 2009;2:173–175. doi: 10.1016/j.rmedc.2009.01.011. - DOI
    1. Caceres M., Ali Z.S., Braud R., Weiman D., Garrett E. Spontaneous pneumomediastinum: A comparative study and review of the literature. Ann Thorac Surg. 2008;86:962–966. doi: 10.1016/j.athoracsur.2008.04.067. - DOI - PubMed
References
    1. Gandhi N.R., Moll A., Sturm A.W., Pawins Ki R., Govender T., Lalloo U., et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006;368:1575–1580. doi: 10.1016/S0140-6736(06)69573-1. - DOI - PubMed
    1. Shah N.S., Wright A., Bai G.H., Barrera L., Boulah B., Martin-Casabona N., et al. Worldwide emergence of extensively drug-resistant tuberculosis. Emerg Infect Dis. 2007;13:380–387. doi: 10.3201/eid1303.061400. - DOI - PMC - PubMed
    1. World Health Organization (WHO). Guidelines for the programmatic management of drug resistance tuberculosis. Emergency Update 2008. Geneva. Available at URL: http://whqlibdoc.who.int/publications/2008/9789241547581_eng.pdf. Accessed on 15th May, 2010.
    1. Shah N.S., Pratt R., Armstrong L., Robison V., Castro K.G., Cegielski J.P. Extensively drug-resistant tuberculosis in the United States, 1993–2007. JAMA. 2008;300:2153–2160. doi: 10.1001/jama.300.18.2153. - DOI - PubMed
    1. Kant L. Childhood tuberculosis: increasing but neglected. Indian J Tuberculosis. 2001;48:1.

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