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. 2012 Jul;85(1015):1011-7.
doi: 10.1259/bjr/68127917. Epub 2012 Jan 17.

Patient-reported complications from fiducial marker implantation for prostate image-guided radiotherapy

S Gill  1 , J Li, J Thomas, M Bressel, K Thursky, C Styles, K H Tai, G M Duchesne, F Foroudi
Affiliations

Patient-reported complications from fiducial marker implantation for prostate image-guided radiotherapy

S Gill et al. Br J Radiol. 2012 Jul.

Abstract

Objectives: To report on complications from transrectal ultrasound-guided insertion of fiducial markers for prostate image-guided radiotherapy.

Methods: 234 patients who underwent transrectal fiducial marker insertion for prostate cancer image-guided radiotherapy were assessed retrospectively by questionnaire with regard to the duration and severity of eight symptoms experienced following the procedure. Pain during the implantation procedure was assessed according to the Wong-Baker faces pain scale.

Results: Of 234 patients, 32% had at least one new symptom after the procedure. The commonest new symptom following the procedure was urinary frequency affecting 16% of patients who had not been troubled by frequency beforehand. Haematuria, rectal bleeding, dysuria and haematospermia affected 9-13% of patients, mostly at Grade 1 or 2. Pain, obstruction, and fever and shivers affected 3-4% of patients. Grade 3 rectal bleeding, haematuria, fever and shivers, and urinary frequency affected 0.5-1.5% of patients. Only one patient had a Grade 4 complication (i.e. fever and shivers). Overall, 9% of patients had symptoms lasting more than 2 weeks. The commonest symptoms that lasted more than 2 weeks were frequency, dysuria, obstructive symptoms and rectal bleeding. Mean pain score during the procedure was 1.1 (range 0-5).

Conclusion: Transrectal ultrasound-guided fiducial marker insertion for image-guided radiotherapy is well tolerated in the majority of prostate cancer patients. Most symptoms were Grade 1 or 2 in severity. Symptoms in the majority of patients last under 2 weeks. The most serious complication was sepsis in our study.

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Figures

Figure 1
Figure 1
Pain score during implantation of fiducial markers (Wong–Baker faces pain scale).
Figure 2
Figure 2
Frequency of new symptoms following insertion of fiducial markers (excluding “no more than usual” and “don't remember”).
Figure 3
Figure 3
Severity of complications by Common Terminology Criteria for Adverse Events (version 3.0) for patients with new symptoms following fiducial implantation, excluding patients that responded as “no more than usual” or “don't remember”.
Figure 4
Figure 4
Duration of symptoms as a percentage excluding patients that did not have symptoms, did not remember or had no more than usual symptoms.
See this image and copyright information in PMC

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