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Case Reports
. 2012 Jan 14;18(2):188-91.
doi: 10.3748/wjg.v18.i2.188.

Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

Roberto J Carvalho-Filho  1 , Janaína Luz Narciso-Schiavon, Luciano H L Tolentino, Leonardo L Schiavon, Maria Lucia G Ferraz, Antonio Eduardo B Silva
Affiliations
Case Reports

Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

Roberto J Carvalho-Filho et al. World J Gastroenterol. .

Abstract

Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients. However, central nervous system (CNS) involvement is uncommon, especially in cryoglobulin-negative subjects. We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia. Significant improvement was observed after antiviral therapy. We discuss the spectrum of neurological manifestations of HCV infection and review the literature.

Keywords: Central nervous system; Hepatitis C; Interferon-α; Polyneuropathy.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging of the head showing a 1.5-cm, high-signal lesion in the left thalamus, suggestive of ischemic injury (arrow).
Figure 2
Figure 2
Necrotic lesions on the right forefoot due to severe vasculitis.
See this image and copyright information in PMC

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