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. 2010 Feb;2(2):181-97.
doi: 10.3390/nu2020181. Epub 2010 Feb 11.

Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats

Megan R Ruth  1 , Ye Wang, Howe-Ming Yu, Susan Goruk, Martin J Reaney, Spencer D Proctor, Donna F Vine, Catherine J Field
Affiliations

Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats

Megan R Ruth et al. Nutrients. 2010 Feb.

Abstract

This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.

Keywords: cytokines; elaidic acid; immune; inflammation; obese; phospholipid; trans fat; vaccenic acid.

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Figures

Figure 1
Figure 1
Mitogen-stimulated IL-2 production. Bars represent mean ± SEM, n=8/group. Bars not sharing a common letter are significantly different (P < 0.05). Ctl, control; VA, vaccenic acid; EA, elaidic acid.
Figure 2
Figure 2
LPS-stimulated cytokine production. Bars represent mean ± SEM, n=8/group. Bars not sharing a common letter are significantly different (P < 0.05). Ctl, control; VA, vaccenic acid; EA, elaidic acid. TNF-α production did not differ among groups (458 ± 42, n = 32).
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