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Review
. 2010 Aug;2(8):790-804.
doi: 10.3390/nu2080790. Epub 2010 Jul 27.

Effect of long-chain polyunsaturated fatty acid supplementation on neurodevelopmental outcome in full-term infants

Mijna Hadders-Algra  1
Affiliations
Review

Effect of long-chain polyunsaturated fatty acid supplementation on neurodevelopmental outcome in full-term infants

Mijna Hadders-Algra. Nutrients. 2010 Aug.

Abstract

It takes more than 20 years before the human brain obtains its complex, adult configuration. Most dramatic developmental changes occur prenatally and early postnatally. During development, long-chain polyunsaturated fatty acids (LCPUFA) such as doxosahexaenoic acid (DHA) and arachidonic acid (AA) are accreted in the brain. Since breastfeeding is associated with a better developmental outcome than formula feeding, and human milk in contrast to traditional standard formula contains LCPUFA, the question arose whether LCPUFA supplementation of infant formula may promote the neurodevelopmental outcome. The current paper reviews the evidence available in full-term infants. It concludes that postnatal supplementation of formula with LCPUFA is associated with a beneficial effect on short-term neurodevelopmental outcome. However, no evidence is available that LCPUFA supplementation enhances neurodevelopmental outcome in full-term infants beyond the age of four months. Nevertheless, it should be realized that very limited information is available on the effect of LCPUFA supplementation on neurodevelopmental outcome at school age or later. It is conceivable that effects of LCPUFA supplementation first emerge or re-emerge at school age when more complex neural functions are expressed.

Keywords: arachidonic acid; breast feeding; cognition; docosahexaenoic acid; full-term; infant; neurodevelopment; LCPUFA.

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References

    1. Hoefer C., Hardy M.C. Later development of breast fed and artificially fed infants. J. Am. Med. Assoc. 1929;92:615–620.
    1. Lanting C.I., Fidler V., Huisman M., Touwen B.C., Boersma E.R. Neurological differences between 9-year-old children fed breast-milk or formula-milk as babies. Lancet. 1994;344:1319–1322. - PubMed
    1. De Jong C., Kikkert H.K., Fidler V., Hadders-Algra M. The Groningen LCPUFA study: no effect of postnatal long-chain polyunsaturated fatty acids in healthy term infants on neurological condition at 9 years. Br. J. Nutr. 2010 Epub ahead of print. - PubMed
    1. Anderson J.W., Johnstone B.M., Remley D.T. Breast-feeding and cognitive development: a meta-analysis. Am. J. Clin. Nutr. 1999;70:525–535. - PubMed
    1. Julvez J., Ribas-Fitó N., Forns M., Garcia-Esteban R., Torrent M., Sunyer J. Attention behaviour and hyperactivity at age 4 and duration of breast-feeding. Acta Paediatr. 2007;96:842–847. - PubMed

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