Case Reports
doi: 10.1111/j.1365-2230.1990.tb02113.x.
Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination
Affiliations
- PMID: 2225539
- DOI: 10.1111/j.1365-2230.1990.tb02113.x
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Case Reports
Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination
Clin Exp Dermatol.
1990 Sep.
Abstract
A 74-year-old woman had been treated with methotrexate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non-healing leg ulcers. After being treated with trimethoprim-sulphamethoxazole for a urinary-tract infection, she developed severe pancytopenia, followed by pneumonia and septic shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged.
Comment in
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Methotrexate interactions.Clin Exp Dermatol. 1991 Jul;16(4):311-2. doi: 10.1111/j.1365-2230.1991.tb00388.x. Clin Exp Dermatol. 1991. PMID: 1794182 No abstract available.
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Methotrexate and trimethoprim-sulphamethoxazole.Clin Exp Dermatol. 1991 May;16(3):231. doi: 10.1111/j.1365-2230.1991.tb00359.x. Clin Exp Dermatol. 1991. PMID: 1934583 No abstract available.
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