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Case Reports
. 1990 Sep;15(5):358-60.
doi: 10.1111/j.1365-2230.1990.tb02113.x.

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination

H Groenendal  1 , F H Rampen
Affiliations
Case Reports

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination

H Groenendal et al. Clin Exp Dermatol. 1990 Sep.

Abstract

A 74-year-old woman had been treated with methotrexate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non-healing leg ulcers. After being treated with trimethoprim-sulphamethoxazole for a urinary-tract infection, she developed severe pancytopenia, followed by pneumonia and septic shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged.

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Comment in

  • Methotrexate interactions.
    Liddle BJ. Liddle BJ. Clin Exp Dermatol. 1991 Jul;16(4):311-2. doi: 10.1111/j.1365-2230.1991.tb00388.x. Clin Exp Dermatol. 1991. PMID: 1794182 No abstract available.
  • Methotrexate and trimethoprim-sulphamethoxazole.
    Verbov JL. Verbov JL. Clin Exp Dermatol. 1991 May;16(3):231. doi: 10.1111/j.1365-2230.1991.tb00359.x. Clin Exp Dermatol. 1991. PMID: 1934583 No abstract available.

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