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. 2012 Jan;18(1):86-90.
doi: 10.3201/eid1801.110556.

Candida spp. with acquired echinocandin resistance, France, 2004-2010

Eric Dannaoui  1 , Marie Desnos-Ollivier, Dea Garcia-Hermoso, Fredéric Grenouillet, Sophie Cassaing, Marie-Thérèse Baixench, Stéphane Bretagne, Françoise Dromer, Olivier Lortholary; French Mycoses Study Group
Collaborators, Affiliations

Candida spp. with acquired echinocandin resistance, France, 2004-2010

Eric Dannaoui et al. Emerg Infect Dis. 2012 Jan.

Abstract

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.

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Figures

Figure
Figure
Corresponding caspofungin (A), micafungin (B), and anidulafungin (C) MICs in 12 Fksp mutant Candida spp. isolates and their wild-type parent isolates, France, 2004–2010. Susceptibility testing was performed by using the European Committee for Antimicrobial Susceptibility Testing method (6) and AM3 medium (7).
See this image and copyright information in PMC

References

    1. Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503–35. 10.1086/596757 - DOI - PMC - PubMed
    1. Baixench MT, Aoun N, Desnos-Ollivier M, Garcia-Hermoso D, Bretagne S, Ramires S, et al. Acquired resistance to echinocandins in Candida albicans: case report and review. J Antimicrob Chemother. 2007;59:1076–83. 10.1093/jac/dkm095 - DOI - PubMed
    1. Pfeiffer CD, Garcia-Effron G, Zaas AK, Perfect JR, Perlin DS, Alexander BD. Breakthrough invasive candidiasis in patients on micafungin. J Clin Microbiol. 2010;48:2373–80. 10.1128/JCM.02390-09 - DOI - PMC - PubMed
    1. Sun HY, Singh N. Characterisation of breakthrough invasive mycoses in echinocandin recipients: an evidence-based review. Int J Antimicrob Agents. 2010;35:211–8. 10.1016/j.ijantimicag.2009.09.020 - DOI - PubMed
    1. Perlin DS. Resistance to echinocandin-class antifungal drugs. Drug Resist Updat. 2007;10:121–30. 10.1016/j.drup.2007.04.002 - DOI - PMC - PubMed

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