Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Jan;18(1):102-4.
doi: 10.3201/eid1801.110471.

Asymmetric type F botulism with cranial nerve demyelination

Alina Filozov  1 , Jessica A Kattan, Lavanya Jitendranath, C Gregory Smith, Carolina Lúquez, Quyen N Phan, Ryan P Fagan
Affiliations
Case Reports

Asymmetric type F botulism with cranial nerve demyelination

Alina Filozov et al. Emerg Infect Dis. 2012 Jan.

Abstract

We report a case of type F botulism in a patient with bilateral but asymmetric neurologic deficits. Cranial nerve demyelination was found during autopsy. Bilateral, asymmetric clinical signs, although rare, do not rule out botulism. Demyelination of cranial nerves might be underrecognized during autopsy of botulism patients.

PubMed Disclaimer

Figures

Figure
Figure
Postmortem cranial nerve tissue from a patient with botulism. A) Fragmentation of myelin sheaths and inflammatory infiltration of B and CD3+ T-cells within the nerve tissue (original magnification ×200). B) B-cell infiltration of nerve tissue; C) CD68-positive myelinoklastic macrophages (original magnification ×400).
See this image and copyright information in PMC

References

    1. Gupta A, Sumner CJ, Castor M, Maslanka S, Sobel J. Adult botulism type F in the United States, 1981–2002. Neurology. 2005;65:1694–700. 10.1212/01.wnl.0000187127.92446.4c - DOI - PubMed
    1. Shapiro RL, Hatheway C, Swerdlow DL. Botulism in the United States: a clinical and epidemiologic review. Ann Intern Med. 1998;129:221–8. - PubMed
    1. Botulism SJ. Clin Infect Dis. 2005;41:1167–73. 10.1086/444507 - DOI - PubMed
    1. Sobel J, Dill T, Kirkpatrick CL, Riek L, Luedtke P, Damrow RA. Clinical recovery and circulating botulinum toxin type F in adult patient. Emerg Infect Dis. 2009;15:969–71. 10.3201/eid1506.070571 - DOI - PMC - PubMed
    1. Fagan RP, Kim H-J. Source of botulinum antitoxin products needs clarification. Pediatr Ann. 2010;39:261–2. - PubMed

Publication types

LinkOut - more resources