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. 2011;1(2):113-122.
doi: 10.1159/000327141. Epub 2011 Apr 15.

An Emerging Role for Understanding Orthostatic Hyp'er'tension in the Cardiorenal Syndrome

Jaya P Buddineni, Laxmi Chauhan, Syed T Ahsan, Adam Whaley-Connell

An Emerging Role for Understanding Orthostatic Hyp'er'tension in the Cardiorenal Syndrome

Jaya P Buddineni et al. Cardiorenal Med. 2011.

Abstract

Orthostatic hypertension (OHT) is a clinically important problem increasingly recognized in persons with borderline hypertension, diabetes mellitus, and autonomic neuropathies, and in the elderly. Moreover, the association of OHT with progression of target end-organ damage, especially coronary heart disease and chronic kidney disease (CKD), and the attendant increased cardiovascular disease (CVD) and CKD risk, is gaining attention but is still underappreciated. There are various mechanisms that contribute to the development of OHT: excessive vascular adrenergic sensitivity, baroreceptor reflex abnormalities, and inappropriate activation of the renin-angiotensin-aldosterone system, which are also mechanisms that lead to cardiorenal metabolic disease (CRS). While the evidence is compelling for the clinical importance of OHT, more investigation is needed to evaluate the effects of OHT on CKD and CVD. The notion that the development of OHT is a risk factor for the development of CRS raises the need for further clinical and investigational attention to this clinical dilemma.

Keywords: Cardiovascular disease; Chronic kidney disease; Hypertension; Orthostatic blood pressure.

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References

    1. Nardo CJ, Chambless LE, Light KC, Rosamond WD, Sharrett AR, Tell GS, Heiss G. Descriptive epidemiology of blood pressure response to change in body position. The ARIC study. Hypertension. 1999;33:1123–1129. - PubMed
    1. Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, Tell GS. Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension. 1992;19(6 Pt 1):508–519. - PubMed
    1. Matsubayashi K, Okumiya K, Wada T, Osaki Y, Fujisawa M, Doi Y, Ozawa T. Postural dysregulation in systolic blood pressure is associated with worsened scoring on neurobehavioral function tests and leukoaraiosis in the older elderly living in a community. Stroke. 1997;28:2169–2173. - PubMed
    1. Thomas RJ, Liu K, Jacobs DR, Jr, Bxild DE, Kiefe CI, Hulley SB. Positional change in blood pressure and 8-year risk of hypertension: the CARDIA Study. Mayo Clin Proc. 2003;78:951–958. - PubMed
    1. Hoshide S, Matsui Y, Shibasaki S, Eguchi K, Ishikawa J, Ishikawa S, Kabutoya T, Schwartz JE, Pickering TG, Shimada K, Kario K, Japan Morning Surge-1 Study Group Orthostatic hypertension detected by self-measured home blood pressure monitoring: a new cardiovascular risk factor for elderly hypertensives. Hypertens Res. 2008;31:1509–1516. - PubMed

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