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. 2011;1(1):45-52.
doi: 10.1159/000322862. Epub 2011 Jan 17.

Diabetic Cardiovascular Disease Predicts Chronic Kidney Disease Awareness in the Kidney Early Evaluation Program

Adam Whaley-Connell, Andrew S Bomback, Samy I McFarlane, Suying Li, Tricia Roberts, Shu-Cheng Chen, Allan J Collins, Keith Norris, George L Bakris, James R Sowers, Peter A McCullough; Kidney Early Evaluation Program Investigators

Diabetic Cardiovascular Disease Predicts Chronic Kidney Disease Awareness in the Kidney Early Evaluation Program

Adam Whaley-Connell et al. Cardiorenal Med. 2011.

Abstract

Aims: Lack of chronic kidney disease (CKD) awareness is common. Recent data suggest that the presence of concurrent diabetes may heighten CKD awareness, but current data have not supported the hypothesis that healthcare delivery or insurance status improves awareness in the diabetic population. Diabetes is associated with high cardiovascular disease (CVD) morbidity, especially in patients with CKD. We hypothesized that a highly prevalent co-morbid condition such as CVD in patients with diabetes would predict CKD awareness.

Methods: We utilized data from theNational Kidney Foundation-Kidney Early Evaluation Program (KEEPTM), a large screening program designed to identify high-risk individuals for CKD and promote awareness.

Results: Among 77,077 participants, CKD was identified in 20,200 and diabetes in 23,082. Prevalence of CVD was higher in participants with than without diabetes (39.5 vs. 22.0%) and in stage 3-5 compared to stage 1-2 CKD (43.3 vs. 34.4%). Patients with diabetes and CVD had a higher level of awareness than those without diabetes (8.2 vs. 2.2%). Among patients with diabetes and CVD, the presence of congestive heart failure was a better predictor of awareness [odds ratio (OR) 1.84; 95% confidence interval (CI) 1.40-2.43] than endpoints such as myocardial infarction or stroke [OR 1.35 (95% CI 1.04-1.73) and OR 1.34 (95% CI 1.04-1.72), respectively].

Conclusions: While prevalence of CKD awareness remained low, our data suggest that in patients with diabetes the presence of CVD was associated with increased awareness in a targeted screening program for CKD awareness.

Keywords: Cardiovascular disease; Chronic kidney disease; Diabetes mellitus; KEEP.

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Figures

Fig. 1
Fig. 1
Prevalence of CVD according to CKD stage and diabetes status.
Fig. 2
Fig. 2
Prevalence of CVD in patients with CKD according to awareness and diabetic status.
Fig. 3
Fig. 3
Prevalence of CKD awareness among KEEP participants stratified by diabetes mellitus (DM) status and CVD status (a) and DM status and individual CVD endpoints (b).
See this image and copyright information in PMC

References

    1. Plantinga LC, Boulware LE, Coresh J, Stevens LA, Miller ER, 3rd, Saran R, Messer KL, Levey AS, Powe NR. Patient awareness of chronic kidney disease: trends and predictors. Arch Intern Med. 2008;168:2268–2275. - PMC - PubMed
    1. Saab G, Whaley-Connell A, McCullough P, Bakris GL. Chronic kidney disease awareness: the Kidney Early Evaluation Program (KEEP) Am J Kidney Dis. 2008;52:382–383. - PubMed
    1. Whaley-Connell A, Sowers JR, McCullough PA, Roberts T, McFarlane SI, Chen SC, Li S, Wang C, Collins AJ, Bakris GL, KEEP Investigators Diabetes mellitus and CKD awareness: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) Am J Kidney Dis. 2009;53(S4):S11–S21. - PubMed
    1. KDOQI KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis. 2007;49(2 suppl 2):S12–S154. - PubMed
    1. U.S. Renal Data System . USRDS 2006 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006.

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