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Comment
. 2012 Jan 18;481(7381):269-70.
doi: 10.1038/481269a.

Genomics: The path to retinoblastoma

Julien Sage, Michael L Cleary
Comment

Genomics: The path to retinoblastoma

Julien Sage et al. Nature. .

Abstract

Genomic analyses of tumours of the childhood cancer retinoblastoma reveal a low mutation rate, challenging the view that genomic instability is crucial for its progression. The work also identifies a new therapeutic target.

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Comment on

  • A novel retinoblastoma therapy from genomic and epigenetic analyses.
    Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. Zhang J, et al. Nature. 2012 Jan 11;481(7381):329-34. doi: 10.1038/nature10733. Nature. 2012. PMID: 22237022 Free PMC article.

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