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. 2012:737:175-9.
doi: 10.1007/978-1-4614-1566-4_26.

High-resolution simultaneous mapping of mitochondrial redox state and glucose uptake in human breast tumor xenografts

H N Xu  1 , G Zheng, S Nioka, B Chance, L Z Li
Affiliations

High-resolution simultaneous mapping of mitochondrial redox state and glucose uptake in human breast tumor xenografts

H N Xu et al. Adv Exp Med Biol. 2012.
No abstract available

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Figures

Fig. 26.1
Fig. 26.1
Typical mitochondrial redox state and Pyro-2DG uptake images and their corresponding histograms of a representative MDA-MB-231 tumor (the tumor section had no scar). The Fp redox ratio, NADH redox ratio, and normalized Pyro-2DG range between 0 and 1; the Fp, NADH, and Pyro-2DG images are in the unit of μM in reference to the corresponding standards. The mean values and the corresponding standard deviations of these indices are also shown on the x-axes of the histograms. The y-axes represent the number of pixels in the tumor section having a specific value of the indices shown by the x-axes of the histograms
See this image and copyright information in PMC

References

    1. Kallinowski F, Vaupel P, Runkel S, et al. Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. Cancer Res. 1988;48:7264–7272. - PubMed
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    1. Xu HN, Nioka S, Glickson JD, et al. Quantitative mitochondrial redox imaging of breast cancer metastatic potential. J Biomed Opt. 2010;15:036010. - PMC - PubMed
    1. Xu HN, Zhou R, Nioka S, et al. Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials. Adv Exp Med Biol. 2009;645:247–253. - PMC - PubMed

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