Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012:5:19-21.
doi: 10.2147/IJGM.S26115. Epub 2012 Jan 4.

Invasive ductal carcinoma within fibroadenoma and lung metastases

Zuhair Abu-Rahmeh  1 , William Nseir, Inna Naroditzky
Affiliations
Case Reports

Invasive ductal carcinoma within fibroadenoma and lung metastases

Zuhair Abu-Rahmeh et al. Int J Gen Med. 2012.

Abstract

Fibroadenomas are one of the most common benign tumors of the breast. Malignant transformation from fibroadenoma to cancer is rare. We present a case of an invasive ductal carcinoma within an otherwise benign fibroadenoma with lung metastasis in a 69-year-old woman.

Keywords: benign tumor; invasive ductal carcinoma; lung metastasis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Ultrasonography revealed a well-circumscribed homogeneous hypoechoic mass 5 cm in diameter.
Figure 2
Figure 2
Mammography in May 2011 revealed well-defined, rounded, and oval masses, some with coarse calcifications and the largest being 5 cm in diameter (white arrow).
Figure 3
Figure 3
Mammography in February 2010 revealed well-defined, rounded and oval masses, some with coarse calcifications the largest being 3 cm in diameter (white arrow).
Figure 4
Figure 4
Within the typical fibroadenoma, irregular groups of invasive carcinoma cells are seen in the stroma (arrows). Hematoxylin and eosin (HE) ×50.
Figure 5
Figure 5
Nests of invasive carcinoma (arrow). Hematoxylin and eosin (HE) ×100.
Figure 6
Figure 6
Myoepithelial cells are absent in invasive carcinoma (black arrow), and myoepithelial cells are preserved in fibroadenoma structures (white arrow). Calponin immunostain ×100.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Greenberg R, Skornick Y, Kaplan O. Management of breast fibroadenomas. J Gen Intern Med. 1998;13:640–645. - PMC - PubMed
    1. Kujiper A, Preisler-Adams SS, Rahusen FD, Gille JJP, Wall E, van Diest PJ. Multiple fibroadenomas harboring carcinoma in situ in a woman with a family history of breast/ovarian cancer. J Clin Pathol. 2002;55:795–797. - PMC - PubMed
    1. Kujiper A, Mommers EC, Van der Wall, Van Diest PJ. Histopathology of the fibroadenomas of the breast. Am J Clin Pathol. 2001;115:736–742. - PubMed
    1. Dupont WD, Page DL, Parl FF, et al. Long term risk of breast cancer in women with fibroadenoma. N Engl J Med. 1994;331:10–15. - PubMed
    1. Buzanowski-Konakry K, Harrison EG, Jr, Payne WS. Lobular carcinoma arising in fibroadenoma of the breast. Cancer. 1975;35:450–456. - PubMed

Publication types