doi: 10.1021/np2009169.
Epub 2012 Jan 19.
Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens
Affiliations
- PMID: 22260257
- DOI: 10.1021/np2009169
Item in Clipboard
Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens
J Nat Prod.
.
Abstract
Nine new alkaloids, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.
Similar articles
-
Cytotoxic indole alkaloids from Melodinus tenuicaudatus.J Nat Prod. 2010 Jun 25;73(6):1075-9. doi: 10.1021/np100086x. J Nat Prod. 2010. PMID: 20462230
-
Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.J Nat Prod. 2010 Jan;73(1):22-6. doi: 10.1021/np900595v. J Nat Prod. 2010. PMID: 20041704
-
Melosuavines A-H, cytotoxic bisindole alkaloid derivatives from Melodinus suaveolens.J Nat Prod. 2013 Dec 27;76(12):2322-9. doi: 10.1021/np4007469. Epub 2013 Nov 25. J Nat Prod. 2013. PMID: 24274642
-
Progress of pharmacological studies on alkaloids from Apocynaceae.J Asian Nat Prod Res. 2013;15(2):166-84. doi: 10.1080/10286020.2012.747521. Epub 2012 Dec 19. J Asian Nat Prod Res. 2013. PMID: 23249181 Review.
-
Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.Molecules. 2016 Nov 14;21(11):1525. doi: 10.3390/molecules21111525. Molecules. 2016. PMID: 27854259 Free PMC article. Review.
Cited by
-
Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2. Sci Rep. 2018. PMID: 30006510 Free PMC article.
-
Acetylcholinesterase immobilized capillary reactors coupled to protein coated magnetic beads: a new tool for plant extract ligand screening.Talanta. 2013 Nov 15;116:647-52. doi: 10.1016/j.talanta.2013.07.046. Epub 2013 Jul 31. Talanta. 2013. PMID: 24148457 Free PMC article.
-
Pharmacokinetics, Tissue Distribution, Plasma Protein Binding Studies of 10-Dehydroxyl-12-Demethoxy-Conophylline, a Novel Anti-Tumor Candidate, in Rats.Molecules. 2019 Jan 14;24(2):283. doi: 10.3390/molecules24020283. Molecules. 2019. PMID: 30646543 Free PMC article.
-
Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells.RSC Med Chem. 2023 Mar 1;14(4):710-714. doi: 10.1039/d3md00049d. eCollection 2023 Apr 26. RSC Med Chem. 2023. PMID: 37122543 Free PMC article.
-
Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.Toxins (Basel). 2017 Apr 28;9(5):150. doi: 10.3390/toxins9050150. Toxins (Basel). 2017. PMID: 28452946 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
