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. 2012 Oct;32(10):770-6.
doi: 10.1038/jp.2011.194. Epub 2012 Jan 19.

Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome

M Yamamoto  1 , S L Feigenbaum, Y Crites, G J Escobar, J Yang, A Ferrara, J C Lo
Affiliations

Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome

M Yamamoto et al. J Perinatol. 2012 Oct.

Abstract

Objective: To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).

Study design: Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.

Result: Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.

Conclusion: A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
The Percentage of Preterm Deliveries among Non-diabetic PCOS and Non-PCOS Women with Singleton Pregnancy. * p< 0.01 comparing PCOS to non-PCOS women
Figure 2
Figure 2
Proportion of Singleton Preterm Delivery by Race/Ethnicity in PCOS and non-PCOS Women * p <0.05 compared to White women for PCOS and non-PCOS subsets. † p < 0.01 comparing PCOS to non-PCOS women
Figure 3
Figure 3
Singleton Preterm Delivery Etiology and Gestational Age Category among Pregnant Women with Polycystic Ovary Syndrome
See this image and copyright information in PMC

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