Epidemiology of respiratory syncytial virus infection in preterm infants

Abstract

This review focuses on the burden of respiratory syncytial virus (RSV) infection in preterm infants with and without chronic lung disease (bronchopulmonary dysplasia, BPD). The year-to-year and seasonal variations in RSV activity are key aspects of RSV epidemiology, and knowledge/monitoring of local RSV activity is mandatory for guidance of prophylaxis with the monoclonal antibodies palivizumab and in the near future motavizumab. Morbidity expressed in rates of hospitalizations attributable to RSV illness revealed a mean of 10 percent in preterm infants without and 19 percent (p=0.016) with BPD. Mortality rates diverged widely, and case fatality rates have been reported to range from 0 to 12 percent. The typical clinical picture of lower respiratory tract infection is not different in term and preterm infants, but rates of apnoeas are significantly increased in preterms, ranging from 4.9 to 37.5 percent with decreasing rates observed in more recent studies. Until a RSV vaccine is developed and will be available, prophylaxis with palivizumab is the only preventative strategy other than hand hygiene and contact measures that significantly reduces RSV hospitalization rates in preterm infants both with and without BPD.

Keywords: Bronchopulmonary dysplasia; monoclonal antibodies; palivizumab; preterms; preventative strategy..

Fig. (1)

(a). Seasonal distribution of rehospitalisations due to respiratory illness (proven RSV and non-RSV infections) in premature infants of 29–36 weeks gestational age [24]. (b). Seasonal distribution of RSV hospitalizations (n=38) in premature infants of 29–32 weeks’ gestational age between 1 June 2001 and 1 June 2003 [11].