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. 2010 Mar;2(1):52-6.

Regulation of calcium signaling in lung cancer

Haihong Yang  1 , Qi Zhang, Jianxing He, Wenju Lu
Affiliations

Regulation of calcium signaling in lung cancer

Haihong Yang et al. J Thorac Dis. 2010 Mar.

Abstract

Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium signaling in lung cancer. Altered expression of specific Ca(2+) channels and Ca(2+)-binding proteins are characterizing features of lung cancer, which regulate cell signaling pathway leading to cell proliferation or apoptosis. Chemoresistance is frequent in lung cancer. Altered endoplasmic reticulum Ca(2+) homeostasis of lung cancer cell is correlated with drug resistance. Hypoxia has a vital role in tumor angiogenesis, metastasis, apoptosis. And Ca(2+) channels are open induced by hypoxia with the increase of Ca(2+) influx causing tumor growth.

Keywords: calcium; calcium channels; calcium-binding protein; endoplasmic reticulum; lung cancer.

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Conflict of interest statement

No potential conflict of interest.

Figures

Fig. 1
Fig. 1. Calcium releasing from ER or influx from the extra cell
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