Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:230386.
doi: 10.1155/2012/230386. Epub 2012 Jan 4.

Cyclosporine: a review

Dustin Tedesco  1 , Lukas Haragsim
Affiliations

Cyclosporine: a review

Dustin Tedesco et al. J Transplant. 2012.

Abstract

The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has since led to the widely accepted view that there is a chronic more irreversible component to this agent as well. Since that time, there has been intense interest in finding protocols which seek to minimize and even avoid the use of calcineurin inhibitors altogether. We seek to review cyclosporine in terms of its mechanism of action, pathophysiologic, and histologic features associated with acute and chronic nephrotoxicity and recent studies looking to avoid its toxic side effects.

PubMed Disclaimer

References

    1. Borel JF. Comparative study of in vitro and in vivo drug effects on cell mediated cytotoxicity. Immunological Communications. 1976;31(4):631–641. - PMC - PubMed
    1. Harder F, Loertscher R, Thiel G. Cyclosporin in cadaveric renal transplantation: one-year follow-up of a multicentre trial. The Lancet. 1983;2(8357):986–989. - PubMed
    1. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. The New England Journal of Medicine. 2000;342(9):605–612. - PubMed
    1. Calne RY, Thiru S, White DJG. Cyclosporin A in patients receiving renal allografts from cadaver donors. The Lancet. 1978;2(8104):1323–1327. - PubMed
    1. Calne RY, Rolles K, White DJG. Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. The Lancet. 1979;2(8151):1033–1036. - PubMed

LinkOut - more resources