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. 2012 Jul;12(6):611-8.
doi: 10.2174/187152012800617713.

Anticancer activity and anti-inflammatory studies of 5-aryl-1,4-benzodiazepine derivatives

Cortez-Maya Sandra  1 , Cortes Cortes Eduardo, Hernandez-Ortega Simon, Ramirez Apan Teresa, Nieto Camacho Antonio, Irina V Lijanova, Martinez-Garcia Marcos
Affiliations

Anticancer activity and anti-inflammatory studies of 5-aryl-1,4-benzodiazepine derivatives

Cortez-Maya Sandra et al. Anticancer Agents Med Chem. 2012 Jul.

Abstract

A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

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