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Comment
. 2012 Jan 17;22(1):7-9.
doi: 10.1016/j.devcel.2011.12.012.

Targeting mechanisms in myelinated axons: not all nodes are created equal

David A Lyons  1 , William S Talbot
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Targeting mechanisms in myelinated axons: not all nodes are created equal

David A Lyons et al. Dev Cell. .
Free article

Abstract

A recent Neuron paper by Zhang et al. (2012) reveals how ion channels and adhesion molecules essential for rapid nerve conduction in vertebrates are differentially targeted to nodes of Ranvier. Moreover, distinct mechanisms regulate initial clustering and maintenance of specific nodal components.

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