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Comment
. 2012 Jan 17;21(1):5-7.
doi: 10.1016/j.ccr.2011.12.019.

Polycomb regulates NF-κB signaling in cancer through miRNA

Iris Uribesalgo  1 , Cecilia Ballaré, Luciano Di Croce
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Polycomb regulates NF-κB signaling in cancer through miRNA

Iris Uribesalgo et al. Cancer Cell. .
Free article

Abstract

The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell, Yamagishi et al. demonstrate that Polycomb-mediated silencing of miR-31 is implicated in the aberrant activation of NF-κB signaling in tumors.

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