Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Feb 15;71(4):280-1.
doi: 10.1016/j.biopsych.2011.12.006.

Child abuse and psychiatric illness

Joan Kaufman  1
Affiliations
Comment

Child abuse and psychiatric illness

Joan Kaufman. Biol Psychiatry. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Brain Regions Involved In the Stress Response
As discussed in the text, several brain regions and interconnected neural circuits that regulate emotion, reward, and executive function are also involved in the stress response. Given the overlap in the stress system and these other brain circuits, it is not surprising that severe stress in the form of child maltreatment is associated with increased risk for a range of psychiatric and substance use disorders which are frequently comorbid with one another. Key: ACC=anterior cingulate cortex; ACTH=adrenocorticotropin hormone; Amy=amygdala; CRH=corticotropin releasing hormone; Hp=hippocampus; LC=locus coerelus; mPFC=medial prefrontal cortex; NAc=nucleus accumbens; OFC=orbitofrontal cortex; VTA=ventral tegmental area. (Adapted from Kaufman and Weder, 2010).
See this image and copyright information in PMC

Comment on

References

    1. Dannlowski U, et al. Limbic scars: Long-term consequences of childhood maltreatment revealed by functional and structural MRI. Biological Psychiatry. 2012 - PubMed
    1. Nikulina V, Widom CS, BLM Child Abuse and Neglect, MAOA, and Mental Health Outcomes: A Prospective Examination. Biological Psychiatry. 2012 - PMC - PubMed
    1. Woon FL, Sood S, Hedges DW. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(7):1181–8. - PubMed
    1. Caspi A, et al. Role of genotype in the cycle of violence in maltreated children. Science. 2002;297(5582):851–4. - PubMed
    1. Kaufman J, Weder N. Neurobiology of Early Life Stress: Evolving Concepts. In: Martin Andres, MD, MPH, Scahill Lawrence, PhD, Kratochvil Christopher J., MD, editors. Pediatric Psychopharmacology. Oxford University Press; New York, NY: 2010. pp. 112–123.

Publication types

Substances