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. 1990 Sep;45(3):172-6.
doi: 10.1111/j.1600-0609.1990.tb00447.x.

Immunophenotype of hairy-cell leukemia

I B Hassan  1 , H Hagberg, C Sundström
Affiliations

Immunophenotype of hairy-cell leukemia

I B Hassan et al. Eur J Haematol. 1990 Sep.

Abstract

15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B-cell phenotype different from that of B-CLL was observed (CD10-, CD19+, CD20+, CD21-, CD22+, CD37+, CD38-, FMC7+, LN1+, PCA-1+, BLy7+ and CD5-). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B-cell leukemias, which is closer to the plasma cell stage of differentiation than that of B-CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.

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