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. 1990 Sep 17;270(1-2):15-8.
doi: 10.1016/0014-5793(90)81224-c.

N-myc suppression and cell cycle arrest at G1 phase by prostaglandins

N Marui  1 , T Sakai, N Hosokawa, M Yoshida, A Aoike, K Kawai, H Nishino, M Fukushima
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N-myc suppression and cell cycle arrest at G1 phase by prostaglandins

N Marui et al. FEBS Lett. .

Abstract

Effects of cyclopentenone prostaglandins, delta 12-prostaglandin (PG) J2 and PGA2 on the expression of N-myc in relation to the effects on cell cycle progression were investigated using human neuroblastoma cell line GOTO. Both PGs suppressed N-myc expression within several hours prior to inducing G1 arrest. The N-myc suppression with delta 12-PGJ2 was continued but with PGA2 it was gradually released, followed by the release of G1 arrest. These results suggest that delta 12-PGJ2 and PGA2 inhibit cell cycle progression in strong association with N-myc suppression and delta 12-PGJ2 is more potent and has a longer effect than PGA2.

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