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Multicenter Study
. 2012 Sep;29(9):1148-52.
doi: 10.1111/j.1464-5491.2012.03591.x.

Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study

E J Mayer-Davis  1 , C Davis, J Saadine, R B D'Agostino Jr, D Dabelea, L Dolan, S Garg, J M Lawrence, C Pihoker, B L Rodriguez, B E Klein, R Klein; SEARCH for Diabetes in Youth Study Group
Affiliations
Multicenter Study

Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study

E J Mayer-Davis et al. Diabet Med. 2012 Sep.

Abstract

Aims: The aim of this pilot study was to generate an initial estimate of the prevalence and correlates of diabetic retinopathy in a racially and ethnically diverse sample of youth with Type 1 and Type 2 diabetes mellitus.

Methods: A pilot study was conducted among 222 individuals with Type 1 diabetes (79% non-Hispanic white, 21% other) and 43 with Type 2 diabetes (28% non-Hispanic white, 72% other), all of > 5 years duration (mean duration 6.8 years) who participated in the SEARCH for Diabetes in Youth study. Diabetic retinopathy was assessed using non-mydriatic retinal photography of both eyes.

Results: The prevalence of diabetic retinopathy was 17% for Type 1 diabetes and 42% for Type 2 diabetes (odds ratio 1.50, 95% CI 0.58-3.88; P = 0.40 adjusted for age, duration, gender, race/ethnicity, parental education and HbA(1c). HbA(1c) was significantly higher among those with any diabetic retinopathy (adjusted mean 79 mmol/mol, 9.4%) vs. no diabetic retinopathy (adjusted mean 70 mmol/mol, 8.6%) (P = 0.015). LDL cholesterol was also significantly higher among those with any diabetic retinopathy (adjusted mean 107.2 mg/dl) compared with those without diabetic retinopathy (adjusted mean 97.9 mg/dl) (P = 0.04).

Conclusions: The prevalence of diabetic retinopathy in contemporary young individuals was substantial, particularly among minority youth and those with Type 2 diabetes. Further long-term study of diabetic retinopathy in youth is needed.

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Figures

FIGURE 1
FIGURE 1
Prevalence and severity of diabetic retinopathy among participants in the SEARCH for Diabetes in Youth diabetic retinopathy pilot study: n = 222 with Type 1 diabetes and n = 43 with Type 2 diabetes. For proliferative diabetic retinopathy: n = 0 for Type 1 diabetes; n = 1 for Type 2 diabetes.
See this image and copyright information in PMC

References

    1. Massin P, Erginay A, Mercat-Caudal I, Vol S, Robert N, Reach G, et al. Prevalence of diabetic retinopathy in children and adolescents with type 1 diabetes attending summer camps in France. Diabetes Metab. 2007;33:284–289. - PubMed
    1. Eppens MC, Craig ME, Cusumano J, Hing S, Chan AK, Howard NJ, et al. Prevalence of diabetes complications in adolescents with type 2 compared with type 1 diabetes. Diabetes Care. 2006;29:1300–1306. - PubMed
    1. Mohsin F, Craig ME, Cusumano J, Chan AK, Hing S, Lee JW, et al. Discordant trends in microvascular complications in adolescents with type 1 diabetes from 1990 to 2002. Diabetes Care 2005. 28:1974–1980. - PubMed
    1. Kubin M, Tossavainen P, Hannula V, Lahti S, Hautala N, Falck A. Prevalence of retinopathy in Finnish children and adolescents with type 1 diabetes: a cross-sectional population-based retrospective study. Arch Dis Child. 2011;96:963–968. - PubMed
    1. Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ, Geiss LS, et al. Prevalence of diabetic retinopathy in the United States, 2005–2008. J Am Med Assoc 2010. 304:649–656. - PMC - PubMed

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