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. 2012 Jan 24:12:2.
doi: 10.1186/1471-2415-12-2.

Results at seven years after the use of intracamerular cefazolin as an endophthalmitis prophylaxis in cataract surgery

Pedro Romero-Aroca  1 , Isabel Méndez-Marin, Merce Salvat-Serra, Juan Fernández-Ballart, Matias Almena-Garcia, Javier Reyes-Torres
Affiliations

Results at seven years after the use of intracamerular cefazolin as an endophthalmitis prophylaxis in cataract surgery

Pedro Romero-Aroca et al. BMC Ophthalmol. .

Abstract

Background: To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery.

Methods: A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endophthalmitis over that period were reviewed. The patients were classified in two groups: Group 1 (11,696 patients) operated on between January 1996 and December 2002, Group 2 (13,305 patients) between January 2003 and December 2009 (in whom a 1 mg/0.1 bolus of intracameral cefazolin was instilled).

Results: During the study period, 76 cases of endophthalmitis were observed in Group 1, and seven in Group 2. The rate of postoperative endophthalmitis reduced from 0.63% to 0.05% with a cefazolin injection. The relative risk (RR) for endophthalmitis in Group 1 against group 2 was 11.45 [95% CI 5.72-22.84, p < 0.001].

Conclusions: An intracameral bolus injection of cefazolin (1 mg in 0.1 ml solution) at the conclusion of the cataract surgery significantly reduced the rate of postoperative endophthalmitis.

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References

    1. Jensen MK, Fiscella RG, Moshirfar M, Mooney B. Third- and fourth generation fluoroquinolones: retrospective comparison of endophthalmitis after cataract surgery performed over 10 years. J Cataract Refract Surg. 2008;34:1460–7. doi: 10.1016/j.jcrs.2008.05.045. - DOI - PubMed
    1. O'Brien TP, Arshinoff SA, Mah FS. Perspectives on antibiotics for postoperative endophthalmitis prophylaxis: potential role of moxifloxacin. J Cataract Refract Surg. 2007;33:1790–800. doi: 10.1016/j.jcrs.2007.06.026. - DOI - PubMed
    1. Kowalski RP, Romanowski EG, Mah FS, Yates KA, Gordon YJ. Topical 0.5% moxifloxacin prevents endophthalmitis in an intravitreal injection rabbit model. J Ocul Pharmacol Ther. 2008;24:1–7. doi: 10.1089/jop.2007.0071. - DOI - PubMed
    1. Hariprasad SM, Blinder KJ, Shah GK, Apte RS, Rosenblatt B, Holekamp NM, Thomas MA, Mieler WF, Chi J, Prince RA. Penetration pharmacokinetics of topically administered 0.5% moxifloxacin ophthalmic solution in human aqueous and vitreous. Arch Ophthalmol. 2005;123:39–44. doi: 10.1001/archopht.123.1.39. - DOI - PubMed
    1. Montan PG, Wejde G, Koranyi G, Rylander M. Prophylactic intracameral cefuroxime. Efficacy in preventing endophthalmitis after cataract surgery. J Cataract Refract Surg. 2002;28:977–81. doi: 10.1016/S0886-3350(01)01269-X. - DOI - PubMed

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