doi: 10.1021/ol203418u.
Epub 2012 Jan 24.
Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes
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- PMID: 22272604
- DOI: 10.1021/ol203418u
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Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes
Org Lett.
.
Abstract
Depending on the conditions employed, gold(I)-catalyzed addition of indoles to 3,3-disubstituted cyclopropenes can be controlled to yield either 3-(E)-vinylindoles (3) or bis-indolylalkanes (4). If the cyclopropene substituents are sterically bulky, unprecedented gold-catalyzed oxidation under air occurs to yield bis-indolylalkene (5) and epoxide (6) at room temperature.
© 2012 American Chemical Society
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