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. 2012 Aug;15(7):551-4.
doi: 10.2174/138620712801619122.

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors

Abdelaziz El Maatougui  1 , Jhonny Azuaje, Alberto Coelho, Ernesto Cano, Matilde Yañez, Carmen López, Vicente Yaziji, Carlos Carbajales, Eddy Sotelo
Affiliations

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors

Abdelaziz El Maatougui et al. Comb Chem High Throughput Screen. 2012 Aug.

Abstract

We herein document the discovery of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones as a novel family of platelet aggregation inhibitors. The preliminary optimization study enabled us to establish the most salient features of the structure-activity relationships in this series as well as to identify novel derivatives that are upto 60 times more potent than the hit structure 1 and slightly superior to the reference drug Milrinone.

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