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Editorial
. 2012 Mar;59(3):539-41.
doi: 10.1161/HYPERTENSIONAHA.111.188714. Epub 2012 Jan 23.

Angiotensin II infusion model of hypertension: is there an important sympathetic component?

Thomas E Lohmeier
Editorial

Angiotensin II infusion model of hypertension: is there an important sympathetic component?

Thomas E Lohmeier. Hypertension. 2012 Mar.
No abstract available

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Figures

Figure
Figure
ANG II has multiple acute and chronic effects to increase blood pressure. However, chronic ANG II hypertension is dependent on the sodium retaining effects of ANG II. Thus, one way ANG II can cause hypertension is by having sustained effects to increase RSNA. In the ANG II infusion model of hypertension, the temporal changes in central sympathetic outflow reflect the balance between the direct excitatory actions of ANG II on the brain and the indirect effects of pressure-mediated baroreflex activation to inhibit sympathetic outflow. Despite the possibility that ANG II may chronically increase RSNA, this action appears to play a minor role in the maintenance of ANG II hypertension. The effects of ANG II that are dominant in mediating chronic hypertension are indicated by the bold arrows in the Figure. ANG II indicates angiotensin II; RSNA, renal sympathetic nerve activity; TPR, total peripheral resistance.
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