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. 2012 Jan;8(1):e1002399.
doi: 10.1371/journal.ppat.1002399. Epub 2012 Jan 19.

How "humane" is your endpoint? Refining the science-driven approach for termination of animal studies of chronic infection

Nuno H Franco  1 , Margarida Correia-Neves, I Anna S Olsson
Affiliations

How "humane" is your endpoint? Refining the science-driven approach for termination of animal studies of chronic infection

Nuno H Franco et al. PLoS Pathog. 2012 Jan.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Russell WMS, Burch RL. The principles of humane experimental technique London: Methuen & Co. Ltd. 1959.
    1. ILAR Humane endpoints for animals used in biomedical research and testing. ILAR Journal. 2000;41
    1. NRC . Washington (D.C.): National Academies Press; 2009. Recognition and alleviation of pain in laboratory animals. - PubMed
    1. Guittin P, Decelle T. Future improvements and implementation of animal care practices within the animal testing regulatory environment. ILAR J 43 Suppl. 2002. pp. S80–S84. - PubMed
    1. OECD . Paris: Organisation for Economic Co-operation and Development; 2000. Guidance document on the recognition, assessment and use of clinical signs as humane endpoints for experiemental animal used in safety evaluation.

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