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. 2012 Jan;5(1):13-22.
doi: 10.1177/1756285611425694.

Smoking: effects on multiple sclerosis susceptibility and disease progression

Dean M Wingerchuk

Smoking: effects on multiple sclerosis susceptibility and disease progression

Dean M Wingerchuk. Ther Adv Neurol Disord. 2012 Jan.

Abstract

Multiple sclerosis (MS) is associated with both genetic and environmental factors that influence disease susceptibility. Exposure to cigarette smoke is emerging as a viable environmental risk factor for MS that contributes to both increased disease susceptibility and more rapid disease advancement. The relative risk for MS development is approximately 1.5 for smokers compared with nonsmokers. Furthermore, there may be important interactions between smoking, an individual's genetic background, and other environmental risk exposures. This review summarizes the current evidence supporting the association of smoking with MS risk and disease course, with additional comments on causation.

Keywords: causality; disease progression; multiple sclerosis; risk factors; smoking.

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Conflict of interest statement

The authors declare no conflicts of interest in preparing this article.

Figures

Figure 1.
Figure 1.
Forest plot of 10 studies included in conservative model meta-analysis of smoking and multiple sclerosis risk [Handel et al. 2011].
Figure 2.
Figure 2.
Forest plot of four studies included in a meta-analysis of smoking and the risk of secondary progressive multiple sclerosis [Handel et al. 2011].
See this image and copyright information in PMC

References

    1. Antonovsky A., Leibowitz U., Smith H.A., Medalie J.M., Balogh M., Kats R., et al. (1965) Epidemiologic study of multiple sclerosis in Israel. I. An overall review of methods and findings. Arch Neurol 13: 183–193 - PubMed
    1. Carlens C., Hergens M.P., Grunewald J., Ekbom A., Eklund A., Hoglund C.O., et al. (2010) Smoking, use of moist snuff, and risk of chronic inflammatory diseases. Am J Respir Crit Care Med 181: 1217–1222 - PubMed
    1. Celius E.G., Smestad C. (2009) Change in sex ratio, disease course and age at diagnosis in Oslo MS patients through seven decades. Acta Neurol Scand Suppl 189: 27–29 - PubMed
    1. Chen H., Huang X., Guo X., Mailman R.B., Park Y., Kamel F., et al. (2010) Smoking duration, intensity, and risk of Parkinson disease. Neurology 74: 878–884 - PMC - PubMed
    1. Compston A., Coles A. (2008) Multiple sclerosis. Lancet 372: 1502–1517 - PubMed

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