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. 2011:2:176.
doi: 10.4103/2152-7806.90696. Epub 2011 Dec 13.

Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): Findings of a multicenter Australian study

Martin Dobes  1 , Vini G Khurana, Bruce Shadbolt, Sanjiv Jain, Sarah F Smith, Robert Smee, Mark Dexter, Raymond Cook
Affiliations

Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): Findings of a multicenter Australian study

Martin Dobes et al. Surg Neurol Int. 2011.

Abstract

Background: The incidence of primary brain tumors by subtype is currently unknown in Australia. We report an analysis of incidence by tumor subtype in a retrospective multicenter study in the state of New South Wales (NSW) and the Australian Capital Territory (ACT), with a combined population of >7 million with >97% retention rate for medical care.

Methods: Data from histologically confirmed primary brain tumors diagnosed from January 2000 through December 2008 were weighted for patient outflow and data completeness, and age standardized and analyzed using joinpoint analysis.

Results: A significant increasing incidence in glioblastoma multiforme (GBM) was observed in the study period (annual percentage change [APC], 2.5; 95% confidence interval [CI], 0.4-4.6, n = 2275), particularly after 2006. In GBM patients in the ≥65-year group, a significantly increasing incidence for men and women combined (APC, 3.0; 95% CI, 0.5-5.6) and men only (APC, 2.9; 95% CI, 0.1-5.8) was seen. Rising trends in incidence were also seen for meningioma in the total male population (APC, 5.3; 95% CI, 2.6-8.1, n = 515) and males aged 20-64 years (APC, 6.3; 95% CI, 3.8-8.8). Significantly decreasing incidence trends were observed for Schwannoma for the total study population (APC, -3.5; 95% CI, -7.2 to -0.2, n = 492), significant in women (APC, -5.3; 95% CI, -9.9 to -0.5) but not men.

Conclusion: This collection is the most contemporary data on primary brain tumor incidence in Australia. Our registries may observe an increase in malignant tumors in the next few years that they are not detecting now due to late ascertainment. We recommend a direct, uniform, and centralized approach to monitoring primary brain tumor incidence by subtype, including the introduction of nonmalignant data collection.

Keywords: Australia; cancer; incidence; late ascertainment; primary brain tumor.

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Figures

Figure 1
Figure 1
US standardized brain tumor incidence rates by major histological groupings by calendar year in the Australian Capital Territory and New South Wales populations for the (a) total population, (b) male population, and (c) female population. Confidence intervals are displayed. Asterisk denotes significance
Figure 2
Figure 2
US standardized brain tumor incidence rates for glioblastoma multiforme by calendar year in the Australian Capital Territory and New South Wales populations for the total population, total population aged 65 years and above, and male population aged 65 years and above. Confidence intervals are displayed. All three trends show a significant (*) increase using joinpoint analysis
Figure 3
Figure 3
US standardized brain tumor incidence rates for meningioma for the total male population and male population aged 20–64 years by calendar year from the Australian Capital Territory and New South Wales populations. Confidence intervals are displayed. Both trends show a significant (FNx01) increase using joinpoint analysis
Figure 4
Figure 4
US standardized brain tumor incidence rates, by sex, of Schwannoma in the Australian Capital Territory and New South Wales populations, by calendar year. Confidence intervals are displayed. Asterisk denotes significance
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