Pharmacological agents that affect sperm motility

Abstract

Male fertility is determined by several factors one of which is essential sperm motility. A large number of drugs have a toxic influence on sperm motility

Material and methods: We tested the influence of some antibacterial antibiotics on rat sperm motility. Following antibiotics were tested antibacterial influences: amoxicillin + clavulanic acid dose of 30 mg/kg body/day, daily and that 150 mg/kgbody/day, daily, respectively ceftazidime dose of 50 mg/kgbody/day, daily and that 250 mg/kgbody/day, daily. For each antibiotic and dose was used by a group of rats that received treatment for 12 days for amoxicillin+clavulanic acid and 11 days, respectively 10 days for ceftazidime. A control group of rats was not received and no substance Sperm motility was determined and histopathological examination of tissues was performed harvested.

Results: Our data showed that the combination of amoxicillin-clavulanic acid in doses of 30 mg/kgbody/day (dose is reached in clinical practice) of sperm motility reduced with 49.33% (p<0.01) and dose of 150 mg/kgbody/day, sperm motility was reduced with 68.96% (p<0.01) ceftazidime doses tested significantly reduced motility of sperm (p<0.01), dose of 50 mg/kgbody/day, sperm motility was reduced with 83.79% and dose of 250 mg/kgbody/day, sperm motility was reduced with 85.36% (p<0.01).

Conclusions: Ceftazidim has a strong effect on sperm cells motility at therapeutic doses. This effect is higher compared to amoxicillin+clavulanic acid association.