Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2012 Apr;21(4):582-93.
doi: 10.1158/1055-9965.EPI-11-1065. Epub 2012 Jan 25.

Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations

Veronika Fedirko  1 , Elio Riboli, Anne Tjønneland, Pietro Ferrari, Anja Olsen, H Bas Bueno-de-Mesquita, Fränzel J B van Duijnhoven, Teresa Norat, Eugène H J M Jansen, Christina C Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Antoine Racine, Annekatrin Lukanova, Birgit Teucher, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Vassiliki Benetou, Dimitrios Trichopoulos, Sara Grioni, Paolo Vineis, Salvatore Panico, Domenico Palli, Rosario Tumino, Peter D Siersema, Petra H Peeters, Guri Skeie, Magritt Brustad, Maria-Dolores Chirlaque, Aurelio Barricarte, Jose Ramón Quirós, Maria José Sánchez, Miren Dorronsoro, Catalina Bonet, Richard Palmqvist, Göran Hallmans, Timothy J Key, Francesca Crowe, Kay-Tee Khaw, Nick Wareham, Isabelle Romieu, James McKay, Petra A Wark, Dora Romaguera, Mazda Jenab
Affiliations
Comparative Study

Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations

Veronika Fedirko et al. Cancer Epidemiol Biomarkers Prev. 2012 Apr.

Abstract

Background: Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown.

Methods: The association between prediagnostic 25(OH)D levels and CRC-specific (N = 444) and overall mortality (N = 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate HRs and corresponding 95% CIs according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle, and metabolic effect modifiers were also investigated.

Results: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (P(trend) = 0.04) and overall mortality (P(trend) = 0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95% CI: 0.50-0.93) for CRC-specific mortality and 0.67 (95% CI: 0.50-0.88) for overall mortality, compared with the lowest quintile. Except for a possible interaction by prediagnostic dietary calcium intake (P(interaction) = 0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival.

Conclusions: High prediagnostic 25(OH)D levels are associated with improved survival of patients with CRC.

Impact: Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Adjusted cumulative incidence curve of colorectal cancer-specific mortality by pre-defined levels of pre-diagnostic 25(OH)D (<50, deficient; 50-74, insufficient; ≥50 nmol/L, sufficient vitamin D status, on the basis of proposed levels of vitamin D deficiency/insufficiency).
See this image and copyright information in PMC

References

    1. Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ, Norat T, Pischon T, et al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study. BMJ. 2010;340:b5500. - PMC - PubMed
    1. Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW, Giovannucci EL. A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst. 2007;99(14):1120–9. - PubMed
    1. Feskanich D, Ma J, Fuchs CS, Kirkner GJ, Hankinson SE, Hollis BW, et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2004;13:1502–1508. - PubMed
    1. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer. 2007;97(3):446–51. - PMC - PubMed
    1. Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet. 1989;2:1176–1178. - PubMed

Publication types

MeSH terms