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. 2012;7(1):e29868.
doi: 10.1371/journal.pone.0029868. Epub 2012 Jan 18.

Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease

Maria Björkqvist  1 , Mattias Ohlsson, Lennart Minthon, Oskar Hansson
Affiliations

Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease

Maria Björkqvist et al. PLoS One. 2012.

Abstract

There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDGF-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Multidimensional scaling plots (MDS) for the data.
The left figure shows a MDS projection to 2 dimensions, using all 18 proteins, for the AD and the Control groups. The right figure is the corresponding plot for the AD and the other dementias group.
See this image and copyright information in PMC

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