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Review
. 2012 Apr;14(2):160-6.
doi: 10.1007/s11883-012-0227-2.

Diabetes and hypertension: is there a common metabolic pathway?

Bernard M Y Cheung  1 , Chao Li
Affiliations
Review

Diabetes and hypertension: is there a common metabolic pathway?

Bernard M Y Cheung et al. Curr Atheroscler Rep. 2012 Apr.

Abstract

Diabetes and hypertension frequently occur together. There is substantial overlap between diabetes and hypertension in etiology and disease mechanisms. Obesity, inflammation, oxidative stress, and insulin resistance are thought to be the common pathways. Recent advances in the understanding of these pathways have provided new insights and perspectives. Physical activity plays an important protective role in the two diseases. Knowing the common causes and disease mechanisms allows a more effective and proactive approach in their prevention and treatment.

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Figures

Fig. 1
Fig. 1
Summary of putative pathophysiologic mechanisms in the development of hypertension in diabetes mellitus. RAAS—renin-angiotensin-aldosterone system; SNS—sympathetic nervous system; VSMC—vascular smooth muscle cell. (From Mugo MN, Stump CS, Rao PG, Sowers JR. Chapter 34: Hypertension and Diabetes Mellitus. Hypertension: A Companion to Braunwald’s Heart Disease. Copyright Elsevier, 2007 [113])
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References

    1. • Cheung BM. The hypertension-diabetes continuum. J Cardiovasc Pharmacol. 2010; 55: 333–9. This is a brief review of the overlap between hypertension and type 2 diabetes that proposes there is a spectrum ranging from hypertension without dysglycemia to type 2 diabetes without elevated blood pressure. - PubMed
    1. Landsberg L, Molitch M. Diabetes and hypertension: pathogenesis, prevention and treatment. Clin Exp Hypertens. 2004;26:621–628. doi: 10.1081/CEH-200031945. - DOI - PubMed
    1. Gress TW, Nieto FJ, Shahar E, et al. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study. N Engl J Med. 2000;342:905–912. doi: 10.1056/NEJM200003303421301. - DOI - PubMed
    1. Cheung BM, Wat NM, Tso AW, et al. Association between raised blood pressure and dysglycemia in Hong Kong Chinese. Diabetes Care. 2008;31:1889–1891. doi: 10.2337/dc08-0405. - DOI - PMC - PubMed
    1. Zeggini E, Scott LJ, Saxena R, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638–645. doi: 10.1038/ng.120. - DOI - PMC - PubMed

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