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. 2012 Mar;60(3):468-73.
doi: 10.1111/j.1532-5415.2011.03836.x. Epub 2012 Jan 27.

Diabetes mellitus in centenarians

Adam Davey  1 , Uday Lele, Merrill F Elias, Gregory A Dore, Ilene C Siegler, Mary A Johnson, Dorothy B Hausman, J Lisa Tenover, Leonard W Poon; Georgia Centenarian Study
Collaborators, Affiliations

Diabetes mellitus in centenarians

Adam Davey et al. J Am Geriatr Soc. 2012 Mar.

Abstract

Objectives: To describe the prevalence of diabetes mellitus (DM) in centenarians.

Design: Cross-sectional, population-based.

Setting: Forty-four counties in northern Georgia.

Participants: Two hundred forty-four centenarians (aged 98-108, 15.8% male, 20.5% African American, 38.0% community dwelling) from the Georgia Centenarian Study (2001-2009).

Measurements: Nonfasting blood samples assessed glycosylated hemoglobin (HbA(1c)) and relevant clinical parameters. Demographic, diagnosis, and DM complication covariates were assessed.

Results: 12.5% of centenarians were known to have DM. DM was more prevalent in African Americans (27.7%) than whites (8.6%, P < .001). There were no differences between men (16.7%) and women (11.7%, P = .41) or between centenarians living in the community (10.2%) and in facilities (13.9%, P = .54). DM was more prevalent in overweight and obese (23.1%) than nonoverweight (7.1%, P = .002) centenarians. Anemia (78.6% vs 48.3%, P = .004) and hypertension (79.3% vs 58.6%, P = .04) were more prevalent in centenarians with DM than in those without, and centenarians with DM took more nonhypoglycemic medications (8.6 vs 7.0, P = .02). No centenarians with HbA(1c) of less than 6.5% had random serum glucose levels greater than 200 mg/dL. DM was not associated with 12-month all-cause mortality, visual impairment, amputations, cardiovascular disease, or neuropathy. Thirty-seven percent of centenarians reported onset before age 80 (survivors), 47% between age 80 and 97 (delayers), and 15% aged 98 and older (escapers).

Conclusion: Diabetes mellitus is a risk factor for cardiovascular disease and mortality but is seen in persons who live into very old age. Aside from higher rates of anemia and use of more medications, few clinical correlates of DM were observed in centenarians.

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References

    1. Christensen K, Doblhammer G, Rau R, et al. Ageing populations: The challenges ahead. Lancet. 2009;374:1196–1208. - PMC - PubMed
    1. Cowie CC, Rust KF, Ford ES, et al. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes care. 2009;32:287–294. - PMC - PubMed
    1. Motta M, Bennati E, Capri M, et al. Diabetes mellitus in the extreme longevity. Exp Gerontol. 2008;43:102–105. - PubMed
    1. American Diabetes Association Standards of medical care in diabetes-2010. Diabetes Care. 2010;33(Supplement):S11. - PubMed
    1. International Expert Committee International expert committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes care. 2009;32:1327–1334. - PMC - PubMed

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