Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function
- PMID: 22284311
- DOI: 10.1016/j.jclinane.2011.09.001
Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function
Abstract
Study objective: To compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function.
Design: Meta-analysis.
Setting: University-affiliated hospital.
Measurements: A systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied.
Main results: There was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79).
Conclusion: Anesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancer patients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment in
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Does anesthetic technique influence cancer?J Clin Anesth. 2012 Feb;24(1):1-2. doi: 10.1016/j.jclinane.2011.10.001. Epub 2011 Dec 6. J Clin Anesth. 2012. PMID: 22154093 No abstract available.
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