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Comment
. 2012 Jan 27;36(1):10-2.
doi: 10.1016/j.immuni.2012.01.006.

The numerology of T cell functional diversity

Affiliations
Comment

The numerology of T cell functional diversity

W Nicholas Haining. Immunity. .

Abstract

Memory T cells are heterogeneous in phenotype and function. In this issue of Immunity, Newell et al. (2012) use a new flow cytometry platform to show that the functional heterogeneity of the human T cell compartment is even greater than previously thought.

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References

    1. Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G. Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels. Science. 2008;321:1081–1084. - PMC - PubMed
    1. Flatz L, Roychoudhuri R, Honda M, Filali-Mouhim A, Goulet J-P, Kettaf N, Lin M, Roederer M, Haddad EK, Sékaly RP, et al. Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines. Proceedings of the National Academy of Sciences. 2011;108:5724–5729. - PMC - PubMed
    1. Kaech SM, Wherry EJ. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity. 2007;27:393–405. - PMC - PubMed
    1. Ma C, Fan R, Ahmad H, Shi Q, Comin-Anduix B, Chodon T, Koya RC, Liu C-C, Kwong GA, Radu CG, et al. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat Med. 2011;17:738–743. - PMC - PubMed
    1. McKinstry KK, Strutt TM, Swain SL. The potential of CD4 T-cell memory. Immunology. 2010;130:1–9. - PMC - PubMed